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SBP0091 – C-Peptide (3-33), human

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SBP0091 – C-Peptide (3-33), human
Proinsulin (33-63), human
MW: 3020.7
Recent reports indicate that this peptide may be biologically active and may stimulate insulin secretion. Prolonged administration of C-Peptide to IDDM patients leads to improved renal and autonomic nervous function. IMPORTANT – Possible confusion on C-Peptide nomenclature: During the cleavage of proinsulin, the N- and C-terminal dipeptide sequences are clipped from the 35-amino acid sequence, proinsulin (31-65), which connects the insulin A and B chains in proinsulin. The designations “Connecting Peptide” and “C-Peptide” have been used in the past to refer to both the 31-amino acid sequence given above, which is the circulating form present in blood, and to the 35 amino acid sequence, C-Peptide (1-35), syn. Proinsulin (31-65). Please ensure that you order only the sequence you require. For C-Peptide (1-35).
Ko, A.S.C. & Smyth, D.G. (1971) Eur. J. Biochem. 20, 190; Oyer, P.E. et al. (1971) J. Biol. Chem.
246, 1375; Igano et al. (1981) Bull. Chem. Soc. Japan 54, 3088; Wahren et al. (1996) J. Internal Med.
240, 115.