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SBP0233 – Orexin A, human

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SBP0233 – Orexin A, human
MW: 3562
pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Cys6-12, Cys7-14, dicyclic)
Orexin A and orexin B are novel hypothalamic neuropeptides discovered by Sakuria et al. (1998) during a search for ligands for orphan G-protein coupled cell surface receptors. These peptides, whose structures are unrelated to any previously known regulatory peptides, are generated by specific proteolytic processing of the single precursor protein prepro-orexin. When administered centrally to rats, these peptides increase prepro-orexin mRNA levels and stimulate food consumption. When food intake was limited, orexin levels increased. They probably play an important role in the physiology of feeding behaviour.
Sakurai, T. et al. (1998) Cell 92, 573.