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SBP0088 – Urocortin, rat

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SBP0088 – Urocortin, rat
MW: 4707.8
Urocortin is a 40 amino acid peptide originally discovered in rat brain. It is a member of the CRF familiy which also includes the frog peptide sauvagine and the fish peptide urotensin. Indeed, urocortin shows a closer sequence homology to urotensin (63%) than to CRF (45%). Urocortin binds more effectively to CRF Type 2 receptors than CRF itself and is probably the endogenous ligand.
Vaughan et al. (1995) Nature 378, 287