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SBP0087 – Urocortin, human

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SBP0087 – Urocortin, human
MW: 4696.8
Following the discovery of urocortin in rat brain, the human peptide was cloned. Human and rat urocortin show 95% sequence homology. Human urocortin has been shown to bind to CRF-1, CRF-2alpha and CRF-2beta receptors as well as CRF-BP. Urocortin is reported to be more effective at suppressing appetite than CRF, but less potent at producing anxiety-like effects.
Donaldson et al. (1996), Endocrinology 137, 2167; Spina et al. (1996) Science 273, 1561.