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SBP0181 – LHRH-III, lamprey

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SBP0181 – LHRH-III, lamprey
MW: 1259.5
Selective FSH-releasing activity has been demonstrated on a number of occasions, but until now the molecule responsible for this action has not been isolated. In view of the FSH-releasing action of LHRH, this peptide has often been postulated to be responsible for both FSH and LH secretion from the pituitary. Recent in vitro and in vivo experiments with rats have shown that lamprey LHRH-III selectively stimulates the release of FSH without affecting LH. It is postulated that this sequence may represent the long sought after endogenous FSH-releasing factor.
Sower, S.A. et al. (1993) Endocrinology 132, 1125; Yu, W.H. et al. (1997) Proc. Soc. Natl. Acad. Sci. USA 94, 9499.