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SBP0016 – Amylin, human

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SBP0016 – Amylin, human
Diabetes-associated Peptide (DAP) Amide, human
MW: 3904.1
H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Cys2-7, cyclic)
Diabetes-associated peptide (DAP), the C-terminal deaminated form of amylin, was originally isolated from amyloid rich pancreatic tissue of diabetic patients. It also occurs in normal adult islet cells. Amylin inhibits basal and insulin stimulated glucose uptake. Both DAP and amylin are active in vivo and in vitro.
Cooper, G.J.S. et al. (1987) Proc. Soc. Natl. Acad. Sci. USA 84, 8628; Westermark, P. et al. (1987) Proc. Soc. Natl. Acad. Sci. 84, 3881.