SBP0038 – [D-Phe6, ß-Ala11, Phe13, Nle14]-Bombesin (6-14)

Description:

SBP0038 – [D-Phe⁶, ß-Ala¹¹, Phe¹³, Nle¹⁴]-Bombesin (6-14)
MW: 1117.4
H-D-Phe-Gln-Trp-Ala-Val-ß-Ala-His-Phe-Nle-NH₂
This bombesin analogue has been found to be a high affinity ligand for the human orphan receptor, bombesin receptor subtype 3 (BRS-3). Neither bombesin itself nor any of its analogues that bind to other bombesin receptor subtypes exhibited significant affinity for BRS-3. Binding of this peptide to BRS-3 stimulates the formation of inositol phosphates. Guanosine 5′-(ß,-imido)-triphosphate causes a change in receptor affinity, preventing binding of this ligand. These results indicate that for a member of the bombesin receptor family, BRS-3 has a unique pharmacological profile. The natural ligand for the BRS-3 receptor subtype is presumably either an undiscovered member of the bombesin family or an unrelated peptide.
Mantey, S.A. et al. (1997) J. Biol. Chem. 272, 26062.
1mg
5mg